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Although mechanisms of bisphenol A action are probably diverse, it should be underlined with respect to the topic of the present review that this EDC increases the generation of hydrogen peroxide (H 2 O 2 ), being one of the basal forms of ROS, in vitro and in vivo models (via increasing DUOX2 [the enzyme responsible for H 2 O 2 generation in the thyroid] mRNA level) and decreases iodine uptake (reduces NIS mRNA level) and TPO activity [45]
Choi, M, Kadara H, Zhang J, Parra Cuentas E, Rodriguez Canales J, Gaffney SG, Zhao Z, Behrens C, Fujimoto J, Chow C, Kalhor N, Moran C, Rimm D, Swisher SG , Gibbons DL, Heymach JV, Kaftan E, Townsend J, Lynch TJ, Schlessinger J, Lee JJ, Lifton R, Herbst RS, Wistuba II
[68:35] Dr
Proteins in the samples were precipitated by boiling or treating with 10 % cold perchloric acid and then centrifuging at 4 C and 12,000 rpm for 10 min
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Youness RA, Dawoud A, EITahawy O, et al
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